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That's me

Benedikt Brors' Home Page

Research Interests:

  • Expression analysis by DNA microarrays
  • Cancer biology
  • Microarray databases
  • Statistics

Short Vita:

  • since 2002: Head of project Computational Oncology in the Division of Theoretical Bioinformatics at DKFZ
  • 2001-2002: Researcher in the Division Intelligent Bioinformatics Systems at DKFZ
  • 1999-2001: Researcher in the Theoretical Bioinformatics Group at DKFZ
  • 1995-1999 PhD student in the Institute of Biochemistry, Heinrich Heine University, Düsseldorf, Germany;
    topic of PhD thesis: Spectroscopy of the mitochondrial complex I (see here)
  • 1989-1995: Studies in chemistry at the Heinrich Heine University, Düsseldorf, Germany
  • born on 10 Feb 1968

Degrees:

  • PhD, Biochemistry, Heinrich Heine University, Düsseldorf, Germany
  • Diploma degree in Chemistry, Heinrich Heine University, Düsseldorf, Germany

Teaching

Publications / Conference Contributions

  1. Czwan E, Brors B, Kipling D. Modelling p-value distributions to improve theme-driven survival analysis of cancer transcriptome datasets.
    BMC Bioinformatics (2010), 11, 19. [pdf]

  2. Letellier E, Kumar S, Sancho-Martinez I, Krauth S, Funke-Kaiser A, Laudenklos S, Konecki K, Klussmann S, Corsini NS, Kleber S, Drost N, Neumann A, Lévi-Strauss M, Brors B, Gretz N, Edler L, Fischer C, Hill O, Thiemann M, Biglari B, Karray S, Martin-Villalba A. CD95-Ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site.
    Immunity (2010), in press.

  3. Fischer M, Bauer T, Oberthür A, Hero B, Theissen J, Ehrich M, Spitz R, Eils R, Westermann F, Brors B, König R, Berthold F. Integrated genomic profiling identifies two distinct molecular subtypes with divergent outcome in neuroblastoma with loss of chromosome 11q.
    Oncogene (2009), e-pub ahead of print. [pdf]

  4. Domschke C, Schuetz F, Ge Y, Seibel T, Falk C, Brors B, Vlodavsky I, Sommerfeldt N, Sinn HP, Kühnle MC, Schneeweiss A, Scharf A, Sohn C, Schirrmacher V, Moldenhauer G, Momburg F, Beckhove P. Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer-Specific Immune Responses and Their Correlation to Prognosis.
    Cancer Res (2009), 69, 8420-8428. [pdf]

  5. Harel L, Costa B, Tcherpakov M, Zapatka M, Oberthuer A, Hansford LM, Vojvodic M, Levy Z, Chen ZY, Lee FS, Avigad S, Yaniv I, Shi L, Eils R, Fischer M, Brors B, Kaplan DR, Fainzilber M. CCM2 Mediates Death Signaling by the TrkA Receptor Tyrosine Kinase.
    Neuron (2009), 63, 585-595 [pdf].

  6. The MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk: Abbas S(*), Beckmann L, Chang-Claude J(*), Hein R(*), Kropp S, Parthimos M, Dünnebier T(*), Hamann U(*), Brors B, Eils R, Zapatka M, Brauch H(*), Justenhoven C(*), Flesch-Janys D(*), Braendle W, Brüning T, Pesch B, Spickenheuer A, Baisch C, Ko YD, Dahmen N, Salazar R(*). Polymorphisms in genes of the steroid receptor superfamily modify postmenopausal breast cancer risk associated with menopausal hormone therapy.
    (*) writing group.
    Int J Cancer (2009), e-pub ahead of print. [pdf]

  7. The MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk: Abbas S, Baisch C, Braendle W, Brauch H, Brors B, Brüning T, Chang-Claude J, Dahmen N, Dünnebier T, Eils R, Flesch-Janys D, Hamann U, Hein R, Justenhoven C, Ko YD, Kropp S, Parthimos M, Pesch B, Spickenheuer A, Zapatka M. Postmenopausal estrogen monotherapy-associated breast cancer risk is modified by CYP17A1_-34_T>C polymorphism.
    Breast Cancer Res Treat (2009), in press. [pdf]

  8. The MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk: Abbas S(*), Beckmann L, Chang-Claude J(*), Hein R(*), Kropp S, Parthimos M, Dünnebier T(*), Hamann U(*), Brors B, Eils R, Zapatka M, Brauch H(*), Justenhoven C(*), Flesch-Janys D(*), Braendle W, Brüning T, Pesch B, Spickenheuer A, Baisch C, Ko YD, Dahmen N, Salazar R(*). Polymorphisms in the BRCA1 and ABCB1 genes modulate menopausal hormone therapy associated breast cancer risk in postmenopausal women.
    (*) writing group.
    Breast Cancer Res Treat (2009), in press. [pdf]

  9. The MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk: Chang-Claude J(*), Beckmann L, Corson C(*), Hein R(*), Kropp S, Parthimos M(*), Dünnebier T(*), Hamann U(*), Brors B, Eils R, Zapatka M(*), Brauch H(*), Justenhoven C(*), Flesch-Janys D, Braendle W, Brüning T, Pesch B, Spickenheuer A, Ko YD, Baisch C, Dahmen N. Genetic polymorphisms in phase I and phase II enzymes and breast cancer risk associated with menopausal hormone therapy in postmenopausal women.
    (*) writing group.
    Breast Cancer Res Treat (2009), in press. [pdf]

  10. Ridder D, Bulashevska S, Chaitanya GV, Babu PP, Brors B, Eils R, Schneider A, Schwaninger M. Discovery of transcriptional programs in cerebral ischemia by in silico promoter analysis.
    Brain Res (2009), 1272, 3-13. [pdf]

  11. Bruns I, Czibere A, Fischer JC, Roels F, Cadeddu RP, Buest S, Bruennert D, Huenerlituerkoglu AN, Stoecklein NH, Singh R, Zerbini LF, Jäger M, Kobbe G, Gattermann N, Kronenwett R, Brors B, Haas R. The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and reflecting loss of quiescence.
    Leukemia (2009), 23, 892-899. [pdf]

  12. Luedde M, Floegel U, Knorr M, Grundt C, Hippe HJ, Brors B, Frank D, Haselmann U, Antony C, Voelkers M, Schrader J, Most P, Lemmer B, Katus H, Frey N. Decreased contractility due to energy deprivation in a transgenic rat model of hypertrophic cardiomyopathy.
    J Mol Med (2009), 87, 411-422. [pdf]

  13. Konrad A, Wies E, Thurau M, Marquardt G, Naschberger E, Hentschel S, Jochmann R, Schulz TF, Erfle H, Brors B, Lausen B, Neipel F, Stürzl M. A systems biology approach to identify combination effects of HHV-8 genes on NF-kappaB activation.
    J Virol (2009), 83, 2563-2574. [pdf]

  14. Pandey P, Brors B, Srivastava PK, Boehn SNE, Bott A, Groene HJ, Gretz N. Microarray-based Approach Identifies microRNAs and their Target Functional Patterns in Polycystic Kidney Disease.
    BMC Genomics (2008), 9, 624. [pdf]

  15. Westermann F, Muth D, Benner A, Bauer T, Henrich KO, Oberthür A, Brors B, Beissbarth T, Vandesompele J, Pattyn F, Hero B, König R, Fischer M, Schwab M. Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas.
    Genome Biol (2008) 9, R150. [pdf]

  16. Oberthür A, Kaderali L, Kahlert Y, Hero B, Westermann F, Berthold F, Brors B, Eils R, Fischer M. Sub-classification and individual survival time prediction from gene expression data of neuroblastoma patients using CASPAR.
    Clin Cancer Res (2008), 14, 6590-6601. [pdf]

  17. Srivastava PK*, Küffer S*, Brors B*, Shahi P, Li L, Kenzelmann M, Gretz N, Gröne HJ. A cut-off based approach for gene expression analysis of formalin-fixed and paraffin embedded tissue samples.
    Genomics (2008), 91, 522-529. [pdf]
    *equal contribution

  18. Zapatka M, Koch Y, Brors B. Ontological Analysis and Pathway Modelling in Drug Discovery.
    Pharm Med (2008), 22, 99-105. [pdf]

  19. Hain T, Hossain H, Chatterjee SS, Machata S, Volk U, Wagner S, Brors B, Haas S, Kuenne CT, Billion A, Otten S, Pane-Farre J, Engelmann S, Chakraborty T. Temporal transcriptomic analysis of the Listeria monocytogenes EGD-e sigmaB regulon.
    BMC Microbiology (2008), 8, 20. [pdf]

  20. Bar Joseph Z, Siegfried Z, Brandeis M, Brors B, Lu Y, Eils R, Dynlacht BD, Simon I. Genome-wide transcriptional analysis of the human cell cycle identifies genes differentially regulated in normal and cancer cells.
    Proc Natl Acad Sci USA (2008), 105, 956-961. [pdf]

  21. Frank D, Kuhn C, Brors B, Hanselmann C, Lüdde M, Katus HA, Frey N. Gene Expression Pattern in Biomechanically Stretched Cardiomyocytes - Evidence for a stretch-specific gene program.
    Hypertension (2008), 51, 309-318. [pdf]

  22. Nowacki S, Skowron M, Oberthuer A, Fagin A, Voth H, Brors B, Westermann F, Eggert A, Hero B, Berthold F, Fischer M. Expression of the tumour suppressor gene CADM1 is associated with favourable outcome and inhibits cell survival in neuroblastoma.
    Oncogene (2007), 27, 3329-3338. [pdf]

  23. Westermann F, Henrich KO, Wei JS, Lutz W, Fischer M, König R, Wiedemeyer R, Ehemann V, Brors B, Ernestus K, Leuschner I, Benner A, Khan J, Schwab M. High Skp2 expression characterizes high-risk neuroblastomas independent of MYCN status.
    Clin Cancer Res (2007), 13, 4695-4703. [pdf]

  24. Bulashevska S, Adebiyi EF, Brors B, Eils R. New insights into genetic regulation of Plasmodium falciparum obtained by Bayesian modeling.
    Gene Reg Syst Biol (2007) 1, 117-129. [pdf]

  25. Warnat P, Oberthür A, Fischer M, Westermann F, Eils R, Brors B. Cross-study analysis of gene expression data for intermediate neuroblastoma identifies two biological subtypes.
    BMC Cancer (2007), 7, 89. [pdf]

  26. Classen S, Zander T, Eggle D, Chemnitz JM, Brors B, Büchmann I, Popov A, Beyer M, Eils R, Debey S, Schultze JL. Human resting CD4+ T cells are constitutively inhibited by TGFβ under steady state conditions.
    J Immunol (2007), 178, 6931-6940 [pdf]

  27. Schramm A, Vandesompele J, Schulte JH, Dreesmann S, Kaderali L, Brors B, Eils R, Speleman F, Eggert A. Translating expression profiling into a clinically feasible test to predict neuroblastoma outcome.
    Clin Cancer Res (2007), 13, 1459-1465. [pdf]

  28. Diaz-Blanco E, Bruns I, Neumann F, Fischer JC, Graef T, Steidl U, Rosskopf M, Brors B, Pechtel S, Bork S, Koch A, Baer A, Rohr UP, Kobbe G, von Haeseler A, Gattermann N, Haas R, Kronenwett R. Molecular signature of CD34+ hematopoietic stem and progenitor cells of patients with CML in chronic phase.
    Leukemia (2007), 21, 494-504. [pdf]

  29. Oberthür A, Warnat P, Kahlert Y, Westermann F, Spitz R, Brors B, Hero B, Eils R, Schwab M, Berthold F, Fischer M. Classification of neuroblastoma patients by published gene-expression markers reveals a low sensitivity for unfavorable courses of MYCN non-amplified disease.
    Cancer Lett (2007), 250, 250-267 [pdf]

  30. Oberthür A, Berthold F, Warnat P, Hero B, Kahlert Y, Spitz R, Ernestus K, König R, Haas S, Eils R, Schwab M, Brors B*, Westermann F*, Fischer M*. Gene-expression based classification of neuroblastoma patients using a customized oligonucleotide-microarray outperforms current clinical risk stratification.
    J Clin Oncol (2006), 24, 5070-5078. [pdf]
    *equal contribution

  31. Manoli T, Gretz N, Gröne HJ, Kenzelmann M, Eils R, Brors B. Group testing for pathway analysis improves comparability of different microarray data sets.
    Bioinformatics (2006), 22:2500-2506. [pdf]

  32. Spitz R, Oberthür A, Zapatka M, Brors B, Hero B, Ernestus K, Oestreich J, Fischer M, Simon T, Berthold F. Oligonucleotide array-based comparative genomic hybridization (aCGH) of 90 neuroblastoma revealed aberration patterns more closely associated with outcome than with stage.
    Genes Chromosomes Cancer (2006), 45:1130-1142. [pdf]

  33. Fischer M, Oberthür A, Brors B, Kahlert Y, Skowron M, Voth H, Warnat P, Ernestus K, Hero B, Berthold F. Differential expression of neuronal genes defines subtypes of disseminated neuroblastoma with favorable and unfavorable outcome.
    Clin Cancer Res (2006), 12:5118-5128. [pdf]

  34. Frank O, Brors B, Li L, Haak M, Merk S, Schwindel U, Zheng C, Müller MC, Fabarius A, Gretz N, Hehlmann R, Hochhaus A, Seifarth W. Gene expresison signatures of primary imatinib-resistant CML patients.
    Leukemia (2006), 20:1400-1407. [pdf]

  35. Zheng C, Hochhaus A, Li L, Haak M, Brors B, Frank O, Giehl M, Schatz M, Weisser A, Lorentz C, Gretz N, Hehlmann R, Seifarth W. Gene expression profiling of CD34+ cells identifies a molecular signature of chronic myeloid leukemia blast crisis.
    Leukemia (2006), 20:1028-1034. [pdf]

  36. Thuerigen O, Schneeweiss A, Toedt G, Warnat P, Hahn M, Kramer H, Brors B, Rudlowski C, Benner A, Schuetz F, Tews B, Eils R, Sinn HP, Sohn C, Lichter P. Gene Expression Signature Predicting Pathologic Complete Response with Gemcitabine, Epirubicin, and Docetaxel in Primary Breast Cancer.
    J Clin Oncol (2006), 24:1839-1845. [pdf]

  37. Bacher CP, Guggiari M, Brors B, Augui S, Clerc P, Avner P, Eils R, Heard E. Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation.
    Nat Cell Biol (2006) 8:293-299. [pdf]

  38. Henrich KO, Fischer M, Mertens D, Benner A, Wiedemeyer R, Brors B, Oberthuer A, Berthold F, Wei JS, Khan J, Schwab M, Westermann F. Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients.
    Clin Cancer Res (2006), 12:131-138. [pdf]

  39. Debey S, Zander T, Brors B, Popov A, Eils R, Schultze JL. A highly standardized, robust, and cost-effective method for genome-wide transcriptome analysis of peripheral blood applicable to large-scale clinical trials.
    Genomics (2006), 87:653-664.

  40. Shahi P, Loukianiouk S, Bohne-Lang A, Kenzelmann M, Küffer S, Maertens S, Eils R, Gröne HJ, Gretz N, Brors B. Argonaute - a database for gene regulation by mammalian microRNAs.
    Nucl Acids Res (2006), 34:D115-D118. [pdf]

  41. Warnat P, Eils R, Brors B. Cross-platform analysis of cancer microarray data improves gene expression based classification of phenotypes.
    BMC Bioinformatics (2005), 6:265. [pdf]

  42. Schramm A, Schulte JH, Klein-Hitpass L, Havers W, Sieverts H, Berwanger B, Christiansen H, Warnat P, Brors B, Eils J, Eils R, Eggert A. Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling.
    Oncogene (2005), 24:7902-7912. [pdf]

  43. Brors B. Microarray annotation and biological information on function.
    Meth Inf Med (2005), 44:468-472. [link]

  44. Derbinsky J, Gäbler J, Brors B, Tierling S, Jonnakuti S, Hergenhahn M, Peltonen L, Walter J, Kyewski B. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels.
    J Exp Med (2005), 202:33-45. [pdf]

  45. Kronenwett R, Butterweck U, Steidl U, Kliszewski S, Neumann F, Bork S, Diaz Blanco E, Roes N, Gräf T, Brors B, Eils R, Maercker C Kobbe G, Gattermann N, Haas R (2005) Distinct molecular phenotype of malignant CD34+ hematopoietic stem and progenitor cells in chronic myelogenous leukemia.
    Oncogene (2005) 24:5313-5324. [pdf]

  46. Neumann F, Teutsch N, Kliszewski S, Bork S, Steidl U, Brors B, Schimkus N, Roes N, Germing U, Hildebrandt B, Royer-Pokora B, Eils R, Gattermann N, Haas R, Kronenwett R. Gene expression profiling of Philadelphia chromosome (Ph) negative CD34+ hematopoietic stem and progenitor cells of patients with Ph positive CML in complete molecular remission during therapy with imatinib.
    Leukemia (2005) 19:458-460. [pdf].

  47. Neben K, Schnittger S, Brors B, Tews B, Kokocinski F, Haferlach T, Müller J, Hahn M, Hiddemann W, Eils R, Lichter P, Schoch C. Analysis of FLT3- and NRAS-activating mutations revealed distinct gene expression patterns in acute myeloid leukemia with normal karyotype. Oncogene (2005) 24:1580-1588. [pdf]

  48. Bulashevska S, Szakacs O, Brors B, Eils R, Kovacs G. Pathways of urothelial cancer progression suggested by Bayesian network analysis of allelotyping data.
    Int J Cancer (2004) 110:850-856. [pdf]

  49. Gotter J, Brors B, Hergenhahn M, Kyewski B. Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters.
    J Exp Med (2004) 199:155-166. [pdf]

  50. Schoch C, Kohlmann A, Schnittger S, Brors B, Dugas M, Mergenthaler S, Kern W, Hiddemann W, Eils R, Haferlach T. Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles.
    Proc Natl Acad Sci USA (2002) 99:10008-10013 [pdf]

  51. Fellenberg K, Hauser NC, Brors B, Hoheisel JD, Vingron M. Microarray data warehouse allowing for inclusion of experiment annotations in statistical analysis.
    Bioinformatics (2002) 18:423-433 [pdf]

  52. Fellenberg K, Hauser, NC, Brors B, Neutzner A, Hoheisel JD, Vingron M. Correspondence anaylsis applied to microarray data.
    Proc Natl Acad Sci USA (2001) 98:10781-10786 [pdf]

  53. Beißbarth T, Fellenberg K, Brors B, Arribas-Prat R, Boer JM, Hauser NC, Scheideler M, Hoheisel JD, Schütz G, Poustka A, Vingron M. Processing and quality control of DNA array hybridization data.
    Bioinformatics (2000) 16:1014-1022. [pdf]

  54. Brors B. Qualitätsstandards für DNA Chip-Analysen (in german).
    Medizinische Genetik (2000) 12:301-303

  55. Rasmussen T, Scheide D, Brors B, Kintscher L, Weiss, H, Friedrich T. Identification of two tetranuclear FeS clusters on the ferredoxin-type subunit of NADH:ubiquinone oxidoreductase (complex I).
    Biochemistry (2001) 40: 6124-6131 [pdf]

  56. Friedrich T, Brors B, Hellwig P, Kintscher L, Rasmussen T, Scheide D, Schulte U, Mäntele W, Weiss H. Characterization of two novel redox groups in the respiratory NADH:Ubiquinone oxidoreductase (complex I).
    Biochim Biophys Acta (2000) 1459:305-309

  57. Schulte U, Haupt V, Abelmann A, Fecke W, Brors B, Rasmussen T, Friedrich T, Weiss H. A reductase/isomerase subunit of mitochondrial NADH:ubiquinone oxidoreductase (complex I) carries an NADPH and is involved in the biogenesis of the complex.
    J Mol Biol (1999) 292:569-580. [pdf]

  58. Schulte U, Abelmann A, Amling N, Brors B, Friedrich T, Kintscher L, Rasmussen T, Weiss H. Search for novel redox groups in mitochondrial NADH:ubiquinone oxidoreductase (complex I) by diode array UV/VIS spectroscopy.
    Biofactors (1998) 8:177-186

  59. Friedrich T, Abelmann A, Brors B, Guénebaut V, Kintscher L, Leonard K, Rasmussen T, Scheide D, Schlitt A, Schulte U, Weiss H. Redox components and structure of the respiratory NADH:ubiquinone oxidoreductase (complex I).
    Biochim Biophys Acta (1998) 1365:215-219

  60. Schneider R, Brors B, Bürger F, Camrath S, Weiss H. Two genes of the putative mitochondrial fatty acid synthase in the genome of Saccharomyces cerevisiae.
    Curr Genet (1997) 32:384-388. [pdf]

  61. Schneider R, Brors B, Massow M, Weiss H. Mitochondrial fatty acid synthesis: a relic of endosymbiontic origin and a specialized means for respiration.
    FEBS Lett (1997) 407:249-252

Book contributions

  1. Brors B. Bioinformatik, in: M. Wink (editor). Molekulare Biotechnologie (2004). Wiley-VCH, Weinheim, Germany. pp. 409-440.

  2. Brors B. Bioinformatics, in: M. Wink (editor). An Introduction to Molecular Biotechnolgoy (2006). Wiley-VCH, Weinheim, Germany. pp. 387-411.

Conference Contributions

  1. Brors B, Beißbarth T. Workshop on: Biosensorik und Data-Mining, Annual Meeting of the Deutsche Gesellschaft für Klinische Chemie und Labormedizin. Mannheim, Germany, Oct 1, 2006.

  2. Brors B. Session Chair for Bioinformatics Session at Annual Meeting of the Deutsche Gesellschaft für Klinische Chemie und Labormedizin. Mannheim, Germany, Oct 1-4, 2006.

  3. Warnat P, Oberthür A, Fischer M, Westermann F, Eils R, Brors B. Meta analysis of gene expression data from non-amplified advanced stage neuroblastoma tumors. Poster, Genomics and Cancer. Heidelberg, Germany, Sep 13-16, 2006.

  4. Brors B. R/Bioconductor for analysis of DNA microarray data; Analyis and quality assessment of microarray data with R/Bioconductor. Invited Talks, FEBS Advanced Course on Microarray and Genosensor Techniques in Biomedical Applications. Prague, Czech Republic, Sep 22-30, 2006.

  5. Brors B, Oberthür A, König R, Berthold F, Warnat P, Schwab M, Eils R, Westermann F, Fischer M. Construction and validation of a neuroblastoma-specific custom microarray. Poster, Advances in Neuroblastoma Research. Los Angeles, CA, USA, May 17-20, 2006.

  6. Brors B. Insight into pathomechanisms of cancerous diseases by bioinformatic analysis of molecular genetic data. Invited Talk, Workshop on Tumor-microenvironment Interaction. Leipzig, Germany, Mar 10, 2006.

  7. Brors B. Cross-platform and vertical analysis of microarray-based gene expression data. Talk, Annual Meeting of the German National Genome Research Network. Bonn, Germany, Nov 19-20, 2005.

  8. Brors B. Gene expression profiling by DNA microarrays as a novel tool in diagnostic of cancerous diseases. Invited Talk, 5th VIB Microarray User Group Meeting. Ghent, Belgium. Nov 17-18, 2005.

  9. Brors B. Construction of a neuroblastoma-specific custom microarray. Invited Talk, Translational Genomics in Neuroblastoma (TGiN), Gaithersburg, MD, USA, Oct 16-18, 2005.

  10. Brors B. R/Bioconductor: Tools for gene expression analysis. Invited Talk, EMBO Practical Course on Microarray Technology: from Production to Systems Biology. EMBL, Heidelberg, Germany, Jun 20-25, 2005.

  11. Brors B. The predictive power of microarrays in the clinic. Invited Talk, ESF Course on "Microarray Gene Expression Analysis: Power and Potential of Standardisation", Trondheim, Norway, May 23-27, 2005.

  12. Brors B. Bioinformatische Datenanalyse in der Diagnostik. Best Practice. Invited Talk, Annual Meeting of the AG Chipdiagnostik of the Deutsche Gesellschaft für Klinische Chemie und Labormedizin. Tutzing, Germany, May 12-13, 2005.

  13. Brors B. Invited Talk, Annual Meeting of Interdisziplinäre Gruppe für Labor und Durchflusszytometrie. Mannheim, Germany, Mar 3-5, 2005.

  14. Kronenwett R, Kliszewski S, Bork S, Butterweck S, Steidl U, Neumann F, Brors B, Gräf T, Roes, N, Eils R, Gattermann N, Haas R. Gene expression profiling of malignant CD34+ hematopoietic stem and progenitor cells in chronic myelogenous leukemia. Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie. Innsbruck, Austria, Oct 2-6, 2004.

  15. Brors B, Warnat P, Eils R. Benchmarking classification analysis applied to microarray data. Poster, 12th International Conference on Intelligent Systems in Molecular Biology (ISMB2005). Jul 31 - Aug 4, 2004, Glasgow, United Kingdom.

  16. Brors B, Warnat P, Eils R. Comparison of machine learning algorithms on different microarray data sets. Talk, Statistical Computing, Reisensburg, Günzburg, Germany, Jul 4-7, 2004.

  17. Schramm A, Schulte JH, Klein-Hitpass L, Sieverts H, Berwanger B, Christiansen H, Simon T, Berthold F, Havers W, Warnat P, Brors B, Eils J, Eils R, Eggert A. Prediction of clinical outcome and biological subclassification of primary neuroblastomas by expression profiling. Talk, Advances in Neuroblastoma Research, Genova, Italy, June 16-19, 2004.

  18. Fischer M, Oberthuer A, Kahlert Y, Brors B, Berthold F. Identification of a gene signature discriminating stage 4S and stage 4 neuroblastoma using serial analysis of gene expression. Talk, Advances in Neuroblastoma Research, Genova, Italy, June 16-19, 2004.

  19. Westermann F, Brors B, Wie J, König R, Wiedemeyer R, Henrich K, Fischer M, Oberthuer A, Berthold F, Khan J, Schwab M. MYCN signnalling pathways in vivo and in vitro. Talk, Advances in Neuroblastoma Research, Genova, Italy, June 16-19, 2004.

  20. Brors B, Frank S. A data mining environment for microarray data: implementation issues and extension to distributed computing systems. 1st Bioinformatics Meeting on Machine Learning for Microarray Studies of Disease: Methods and Web Platforms. Trento/Luserna, Italy, Jun 3-6, 2004.

  21. Brors B. Classification analysis applied to leukemia and neuroblastoma: How bioinformatics can help in improving diagnostics. Invited talk, Microarray Course of GENOSTEM project. Berlin, Germany, May 13-16, 2004.

  22. Brors B. Microarray annotation and biological information. Microarray Analysis Tutorial, German Biometrical Society Meeting, Heidelberg, Germany, Mar 15-19, 2004.

  23. Neben K, Schnittger S, Brors B, Wrobel G, Haferlach T, Müller J, Hahn M, Hiddemann W, Eils R, Lichter P, Schoch C. Gene Expression Patterns in Acute Myeloid Leukemia with FLT3, RAS and MLL Mutations and Normal Karyotype. Poster, 45th Annual Meeting, American Society of Hematology (ASH 2003). San Diego, CA, USA, Dec 6-9, 2003.
    Abstract in: Blood, 102 (11):#1351, 2003.

  24. Steudel C, Brors B, Schaich M, Schaekel U, Illmer T, Eils R, Ehninger G, Thiede C. Transcription Profiling of Adult Acute Myeloid Leukemias with Mutated FTL3. Poster, 45th Annual Meeting, American Society of Hematology (ASH 2003). San Diego, CA, USA, Dec 6-9, 2003.
    Abstract in: Blood, 102 (11):#2224, 2003.

  25. Steudel C, Brors B, Schaich M, Schäkel U, Illmer T, Eils R, Ehninger G, Thiede C. Gene Expression Profiling of Adult Acute Myeloid Leukemias with Mutated FLT3. Poster, Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie. Basel, Switzerland, Oct 4-8, 2003.

  26. Brors B. Connecting Molecular Genetics Research with Systems Biology. Invited talk, Optimization Workshop, Gesellschaft für Operations Research. Heidelberg, Germany, Sep 2, 2003.

  27. Brors B. Bioinformatics: The Art of Integrating Data From Chips. Invited talk, 2nd Int. Symposium on Molecular Diagnostics and Skin Gene Therapy. Düsseldorf, Germany, Mar 27-29, 2003.

  28. Brors B. Microarray Data Analysis and Its Use in Molecular Diagnosis. National Symposium on Microarray Statistics for PhD Students. Ghent, Belgium, Feb 28, 2003.

  29. Brors B. Classification Analysis of Human Leukemia Samples: Correlation Between Genotype, Transcriptome Composition, and Phenotype. Tutorial on Array Informatics, CNRS, Montpellier, France, Jan 13, 2003.

  30. Brors B. Approaches for deciphering complex pathomechanisms in cancer. Invited talk, Jahrestagung der Gesellschaft für Informatik 2002. Dortmund, Germany, Sep 30 - Oct 3, 2002.

  31. Brors B. Aggregation of classifiers makes supervised analysis of molecular genetics data more robust. Talk, Statistical Computing 2002. Reisensburg, Günzburg, Germany, June 23-26, 2002.

  32. Brors B. Classification Using Microarray Data: Old & New Methods, How to Validate the Results, and How to Interpret Them. Invited talk, Silicon Genetics European Users Conference 2002. Stockholm, Sweden, May 30-31, 2002.

  33. Brors B, Kohlmann A, Schnittger S, Schoch C, Haferlach T, Eils R. Classification of cytogenetically defined AML patients by decision tree analysis of statistically selected gene expression data. Poster, 43rd Annual Meeting of the American Society of Hematology (ASH01). Orlando, FL (USA), December 7-12, 2001. [pdf]
    Abstract in: Blood (2001) 98:93a

  34. Brors B. Intelligente Data-Mining-Methoden: Von genomischen Daten zu klinischer Relevanz und neuen Einsichten in Pathomechanismen. Invited talk, Jahrestagung der Deutschen Gesellschaft für klinische Chemie und der Deutschen Gesellschaft für Laboratoriumsmedizin. Rostock, Germany, September 16-19, 2001. [pdf]

  35. Brors B. Bioinformatics: The data, computing and more. Invited talk, 22nd DGPT Symposium "Pharmacogenetics and Pharmacogenomics". Schloß Rauischholzhausen, Germany, June 14-16, 2001. [pdf]

  36. Brors B, Hauser NC, Bastuck S, Hoheisel J. Normalization of data from radioactive hybridization to DNA arrays. Poster, 3rd International Meeting on Microarray Data Standards, Annotations, Ontologies and Databases (MGED3). Stanford Univ., Palo Alto, CA (USA), March 29-31, 2001.

  37. Brors B. Analysis of DNA microarrays as a new field in bioinformatics. Invited talk, SITEF 2000 Colloquium "Perspectives d'Application de la Génomique et de la Post-Génomique". Toulouse, France, 19.-20.10. 2000

  38. Brors B. Expectations of future users about a public gene expression database. Invited talk, Mouse Microarray & Informatics Conference, Hinxton, UK, 28.-30.03. 2000

Bioinformatics Summer School

Here is my tutorial on DNA chips and proteomics for BISS2000 at Bielefeld, Germany.

Talks and Seminars

  • DNA Chip Technology, Statistics seminar 05/01 [pdf] [pdf, german]
  • Bionformatics - The data, computing and more. Talk, DGPT Symposium Rauischholzhausen, 06/01 [pdf]
  • Bootstrapping cluster analysis. Statistics seminar 07/01 [pdf]
  • Intelligente Data-Mining-Methoden: Von genomischen Daten zu klinischer Relevanz und neuen Einsichten in Pathomechanismen. Talk, DGPT-DGLM meeting Rostock, 09/01. [pdf]
  • Kurs "Practical Analysis of Mircroarray Data", Berlin, Germany, Jan 27-30, 2003:

Links



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Address

DKFZ - iBioS (Abt. B080)
Benedikt Brors
Im Neuenheimer Feld 280
69120 Heidelberg, Germany
Phone: +49-6221-42 3614
Fax: +49-6221-42 3620
Email (replace "{at}"): b.brors{at}dkfz.de

Benedikt Brors- Last Change: 11.01.10