The eilslabs form a joint research group between the division "Theoretical Bioinformatics" at the German Cancer Research Center (dkfz) and the department Bioinformatics and Functional Genomics at the Institute of Pharmacy and Molecular Biotechnology (IPMB) at Heidelberg University. The group is headed by Prof. Roland Eils.
Integrative Bioinformatics and Systems Biology
With the advent of next-generation sequencing technologies it is today feasible to determine the sequence of a human individual (e.g. a patient suffering of cancer) in a matter of days. Other, complementary technologies such as transcriptome, proteome or metabolome analysis deliver further huge amounts of data with an enormous potential value for precise diagnostics. Albeit the enormous technological advances in data generation, the integration of these data in order to generate new insights into complex biological function is still a major challenge and can only be achieved with interdisciplinary approaches.
Our division is developing computer-assisted methods for interpreting complex genomic and other biological data as well as methods for modeling and simulation of biological processes. Major activities include the development of integrated bioinformatics approaches for the interpretation and management of cancer genome and clinical data, the application of state-of-the-art technologies in automated live-cell imaging and image analysis, experimental and theoretical systems biology approaches addressing key cellular mechanisms and their distortions in cancer cells as well as the development of new synthetic biology tools to manipulate cellular processes.
Overarching aim is the development of new insights linking alterations in cancer or other diseased cells with biological functions in order to find new potential targets for improved diagnostics and treatment. To achieve this, the eilslabs are actively contributing to DKFZ-HIPO, the Heidelberg Center for Personalized Oncology, which is co-directed by Roland Eils.
Eight research groups are part of the eilslabs:
|Biomedical Computer Vision headed by Karl Rohr|
|Cancer Regulatory Genomics headed by Carl Herrmann|
|Cellular Mechanics headed by Evgeny Gladilin|
|Computational Oncology headed by Matthias Schlesner|
|Data Management and Genomics IT headed by Jürgen Eils and Chris Lawerenz|
|intelligent imaging headed by Christian Conrad|
|Synthetic Biology headed by Barbara Di Ventura|
|Theoretical Systems Biology headed by Roland Eils|
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