GROUP: Cancer Regulatory Genomics

We are interested in understanding how cancer affects the genomic regulatory landscape, both through genetic and epigenetic mechanisms, and what the impact of such remodelling is on gene expression.

 


  • Bauer T, Trump S, Ishaque N, Thürmann L, Gu L, Bauer M, Bieg M, Gu Z, Weichenhan D, Mallm JP,
    Röder S , Herberth G, Takada H, Mücke O, Winter M, Junge KM, Grützmann K , Rolle-Kampczyk U,
    Wang Q, Lawerenz C, Borte M, Polte T, Schlesner M, Schanne M, Wiemann S, Geörg C , Stunnenberg
    HK , Plass C , Rippe K , Mizuguchi J , Herrmann C*, Eils R*, Lehmann I* (*Joint senior authors)
    "Maternal smoking induces stable epigenetic programming of genomic regulatory elements in
    mothers and their children"
    Molecular Systems Biology (2016) accepted
  • S. Steinhauser, N. Kurzawa, R. Eils, C. Herrmann "A comprehensive comparison of tools for differential ChIP-seq analysis" Briefings in Bioinformatics (2016) [link]
  • M. Peifer, F. Hertwig, F. Roels, D. Dreidax et al. "Telomerase activation by genomic rearrangements in high-risk neuroblastoma", Nature (2015) [link]
  • N. Nolte, N. Kurzawa, R. Eils and C. Herrmann "MapMyFlu : visualizing spatio-temporal relationships between related influenza sequences", NAR W547-W551 [link]
  • A. Verfaillie, H. Imrichova, Z. Kalender Atak, M. Dewaele, F. Rambow, G. Hulselmans, V. Christiaens, D. Svetlichnyy, F. Luciani, L. Van den Mooter, S. Claerhout, M. Fiers, F. Journe, GE Ghanem, C.Herrmann, G. Halder, JCMarine, S. Aerts, "Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state" Nature Communications 6-6683 (2015) [link]