GROUP: Computational Oncology

We are adapting methods from machine learning to various data types from molecular genetics. We are developing new methods for their analysis, in particular with applications to oncology.


Highlights

  • Natalie Jäger , Matthias Schlesner, David T.W. Jones, Simon Raffel, Jan-Philipp Mallm, Kristin M. Junge, Dieter Weichenhan, Tobias Bauer, Naveed Ishaque, Marcel Kool, Paul A. Northcott, Andrey Korshunov, Ruben M. Drews, Jan Koster, Rogier Versteeg, Julia Richter, Michael Hummel, Stephen C. Mack, Michael D. Taylor, Hendrik Witt, Benedict Swartman, Dietrich Schulte-Bockholt, Marc Sultan, Marie-Laure Yaspo, Hans Lehrach, Barbara Hutter, Benedikt Brors, Stephan Wolf, Christoph Plass, Reiner Siebert, Andreas Trumpp, Karsten Rippe, Irina Lehmann, Peter Lichter, Stefan M. Pfister, Roland Eils: Hypermutation of the Inactive X Chromosome Is a Frequent Event in Cancer, Cell, Available online 17 October 2013 http://dx.doi.org/10.1016/j.cell.2013.09.042

    Feed-IconRead the news feature: X-Chromosome Hypermutation: New Biological Phenomenon Discovered - Publication in Cell

  • Wang, Q., Gu, L., Adey, A., Radlwimmer, B., Wang, W., Hovestadt, V., Bähr, M., Wolf, S., Shendure, J., Eils, R., Plass, C., & Weichenhan, D. (2013). Tagmentation-based whole-genome bisulfite sequencing. Nature Protocols, 8(10), 2022-2032. doi: 10.1038/nprot.2013.118

    Feed-IconRead the news feature: New publication in Nature Protocols: whole-genome bisulfite sequencing with minute amounts of DNA

  • Jones, D. T. W*., Hutter, B*., Jager, N.*, Korshunov, A., Kool, M., Warnatz, H.-J., ..., Matthias Schlesner, ..., Benedikt Brors, ..., Roland Eils, Peter Lichter, Stefan M Pfister for the International Cancer Genome Consortium PedBrain Tumor Project. (2013). Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nature Genetics, advance online publication. doi: 10.1038/ng.2682

    Feed-IconRead the news feature: Pilocytic astrocytoma is predominantly a single-pathway disease

  • Joachim Weischenfeldt*, Ronald Simon*, Lars Feuerbach*, Karin Schlangen*, Dieter Weichenhan*, Sarah Minner*, Daniela Wuttig*, Hans-Jörg Warnatz, Henning Stehr, Tobias Rausch, Natalie Jäger, Lei Gu, Olga Bogatyrova, Adrian M. Stütz, Rainer Claus, Jürgen Eils, Roland Eils, Clarissa Gerhäuser, Po-Hsien Huang, Barbara Hutter, Rolf Kabbe, Christian Lawerenz, Sylwester Radomski, Cynthia C. Bartholomae, Maria Fälth, Stephan Gade, Manfred Schmidt, Nina Amschler, Thomas Haß, Rami Galal, Jovisa Gjoni, Ruprecht Kuner, Constance Baer, Sawinee Masser, Christof von Kalle, Thomas Zichner, Vladimir Benes, Benjamin Raeder, Malte Mader, Vyacheslav Amstislavskiy, Meryem Avci, Hans Lehrach, Dmitri Parkhomchuk, Marc Sultan, Lia Burkhardt, Markus Graefen, Hartwig Huland, Martina Kluth, Antje Krohn, Hüseyin Sirma, Laura Stumm, Stefan Steurer, Katharina Grupp, Holger Sültmann, Guido Sauter, Christoph Plass, Benedikt Brors, Marie-Laure Yaspo, Jan O. Korbel, Thorsten Schlomm (2013). Integrative Genomic Analyses Reveal an Androgen-Driven Somatic Alteration Landscape in Early-Onset Prostate Cancer. Cancer Cell, 23(2), 159–170. doi:10.1016/j.ccr.2013.01.002
    Feed-IconRead the news feature: Publication in Cancer Cell - Large Feedback in German Newspapers

  • Julia Richter*, Matthias Schlesner*, Steve Hoffmann*, Markus Kreuz*, Ellen Leich*, Birgit Burkhardt*, Maciej Rosolowski, ..., Roland Eils, Ralf Küppers, Michael Hummel, Wolfgang Klapper, Philip Rosenstiel, Andreas Rosenwald, Benedikt Brors, Reiner Siebert; ICGC MMML-Seq Project. 2012. “Recurrent Mutation of the ID3 Gene in Burkitt Lymphoma Identified by Integrated Genome, Exome and Transcriptome Sequencing.” Nature Genetics advance on (November 11). DOI:  http://dx.doi.org/10.1038/ng.2469
    Feed-IconRead the news feature: Deciphering the genome of Burkitt-Lymphomas: Publication in Nature Genetics

  • Jones, David T W*, Natalie Jäger*, Marcel Kool, Thomas Zichner, Barbara Hutter, Marc Sultan, Yoon-Jae Cho, et al. 2012. “Dissecting the Genomic Complexity Underlying Medulloblastoma.” Nature 488 (7409) (August 2): 100–5. DOI:  http://dx.doi.org/10.1038/nature11284
    Feed-IconRead the news feature: Nature Publication on Genomic Analysis of brain tumors