GROUP: Cancer Regulatory Genomics

We are interested in understanding how cancer affects the genomic regulatory landscape, both through genetic and epigenetic mechanisms, and what the impact of such remodelling is on gene expression.

 


icgc_logo_3081The publication decribes results from the analysis of 125 whole genomes (tumor and normal pairs) from Medulloblastoma patients, an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. iBioS scientists were instrumental in carrying out data analysis on the genome data. The work is part of the ICGC PedBrain Tumor consortium.

 

In the first data evaluation, genomic changes which not only reveal targets for new treatment approaches but also provide information about how to use already available drugs more specifically have been discovered. For example, tetraploidy was identified as a frequent early event in certain patient groups.

Full citation:

Jones, D.T.W.*, Jager, N.*, Kool, M., Zichner, T., Hutter, B., Sultan, M., Cho, Y.-J., Pugh, T.J., Hovestadt, V., Stutz, A.M., Rausch, T., Warnatz, H.-J., Ryzhova, M., Bender, S., Sturm, D., Pleier, S., Cin, H., Pfaff, E., Sieber, L., Wittmann, A., Remke, M., Witt, H., Hutter, S., Tzaridis, T., Weischenfeldt, J., Raeder, B., Avci, M., Amstislavskiy, V., Zapatka, M., Weber, U.D., Wang, Q., Lasitschka, B., Bartholomae, C.C., Schmidt, M., von Kalle, C., Ast, V., Lawerenz, C., Eils, J., Kabbe, R., Benes, V., van Sluis, P., Koster, J., Volckmann, R., Shih, D., Betts, M.J., Russell, R.B., Coco, S., Paolo Tonini, G., Schuller, U., Hans, V., Graf, N., Kim, Y.-J., Monoranu, C., Roggendorf, W., Unterberg, A., Herold-Mende, C., Milde, T., Kulozik, A.E., von Deimling, A., Witt, O., Maass, E., Rossler, J., Ebinger, M., Schuhmann, M.U., Fruhwald, M.C., Hasselblatt, M., Jabado, N., Rutkowski, S., von Bueren, A.O., Williamson, D., Clifford, S.C., McCabe, M.G., Peter Collins, V., Wolf, S., Wiemann, S., Lehrach, H., Brors, B., Scheurlen, W., Felsberg, J., Reifenberger, G., Northcott, P.A., Taylor, M.D., Meyerson, M., Pomeroy, S.L., Yaspo, M.-L., Korbel, J.O., Korshunov, A., Eils, R.#, Pfister, S.M.#, and Lichter, P.# (2012). Dissecting the genomic complexity underlying medulloblastoma. Nature advance online publication.

DOI: http://dx.doi.org/10.1038/nature11284

*= equal contribution  # = corresponding author