Welcome to the eilslabs

The eilslabs form a joint research group between the division "Theoretical Bioinformatics" at the German Cancer Research Center (dkfz) and the department Bioinformatics and Functional Genomics at the Institute of Pharmacy and Molecular Biotechnology (IPMB) at Heidelberg University. The group is headed by Prof. Roland Eils.

 


 

In the study, which recently appeared in Cancer Cell, the authors identified previously unknown causes for Wilms tumor, a common childhood tumor of the kidneys. The work was part of the efforts of DKFZ-HIPO, the Heidelberg Center for Personalized Oncology, which funded the sequencing efforts and is a collaboration between the group of Manfred Gessler (University of Würzburg) and the divisions of Stefan Pfister and Roland Eils at DKFZ. Naveed Ishaque, postdoc in the Computational Oncology group of the eilslabs, provided the bioinformatics analysis of the samples and is shared first author. A total of 53 patients samples were analyzed by whole exome sequencing, followed by diverse validation of findings including profiling of mRNA and microRNA expression.

The study shows that mutations in the SIX1/2 transcription factors, which are involved in kidney development, and defects in the microRNA processing machinery underlie many high-risk Wilms tumor – a result which in the future should support the identification of patients in need for more aggressive therapies.

Wegert et al 2015 Cancer Cell

Source:  Reprinted from J. Wegert et al., Cancer Cell 27, 298-311 (2015)  with permission from Elsevier

Citation and Further Information:

  • Wegert, J.*, Ishaque, N. *, Vardapour, R., Geörg, C., Gu, Z., Bieg, M., Ziegler, B., Bausenwein, S., Nourkami, N., Ludwig, N., Keller, A., Grimm, C., Kneitz, S., Williams, Richard D., Chagtai, T., Pritchard-Jones, K., van Sluis, P., Volckmann, R., Koster, J., Versteeg, R., Acha, T., O’Sullivan, Maureen J., Bode, Peter K., Niggli, F., Tytgat, Godelieve A., van Tinteren, H., van den Heuvel-Eibrink, Marry M., Meese, E., Vokuhl, C., Leuschner, I., Graf, N., Eils, R., Pfister, Stefan M., Kool, M., & Gessler, M. (2015). Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors. CANCER CELL, 27(2), 298-311. doi: 10.1016/j.ccell.2015.01.002
  • DKFZ Press Release