Welcome to the eilslabs

The eilslabs form a joint research group between the division "Theoretical Bioinformatics" at the German Cancer Research Center (dkfz) and the department Bioinformatics and Functional Genomics at the Institute of Pharmacy and Molecular Biotechnology (IPMB) at Heidelberg University. The group is headed by Prof. Roland Eils.

 


Integrative Genomic Analyses Reveal an Age-Dependent Mechanism in Early-Onset Prostate Cancer

Cell PressThe ICGC project on early onset prostate cancer, in which the eilslabs are responsible for data analysis and management, has published its first study on the results of the integrative analysis of prostate tumor genomes. Within the study, in which Lars Feuerbach holds a shared first and Benedikt Brors a shared senior authorship, the authors describe remarkable age-related differences in structural rearrangements, indicating distinct disease pathomechanisms between elderly and young patients.

It is noteworthy that this publication, which has remarkable clinical implications, has raised a lot of awareness in large German newspapers (see links at bottom).

Further Information:

  • Original Citation:
    Joachim Weischenfeldt, Ronald Simon, Lars Feuerbach, Karin Schlangen, Dieter Weichenhan, Sarah Minner, Daniela Wuttig, Hans-Jörg Warnatz, Henning Stehr, Tobias Rausch, Natalie Jäger, Lei Gu, Olga Bogatyrova, Adrian M. Stütz, Rainer Claus, Jürgen Eils, Roland Eils, Clarissa Gerhäuser, Po-Hsien Huang, Barbara Hutter, Rolf Kabbe, Christian Lawerenz, Sylwester Radomski, Cynthia C. Bartholomae, Maria Fälth, Stephan Gade, Manfred Schmidt, Nina Amschler, Thomas Haß, Rami Galal, Jovisa Gjoni, Ruprecht Kuner, Constance Baer, Sawinee Masser, Christof von Kalle, Thomas Zichner, Vladimir Benes, Benjamin Raeder, Malte Mader, Vyacheslav Amstislavskiy, Meryem Avci, Hans Lehrach, Dmitri Parkhomchuk, Marc Sultan, Lia Burkhardt, Markus Graefen, Hartwig Huland, Martina Kluth, Antje Krohn, Hüseyin Sirma, Laura Stumm, Stefan Steurer, Katharina Grupp, Holger Sültmann, Guido Sauter, Christoph Plass, Benedikt Brors, Marie-Laure Yaspo, Jan O. Korbel, Thorsten Schlomm (2013). Integrative Genomic Analyses Reveal an Androgen-Driven Somatic Alteration Landscape in Early-Onset Prostate Cancer. Cancer Cell, 23(2), 159–170. doi:10.1016/j.ccr.2013.01.002
  • EMBL Press Release
  • DKFZ Press Release (in German)

Feedback in the German press: