Welcome to the eilslabs

The eilslabs form a joint research group between the division "Theoretical Bioinformatics" at the German Cancer Research Center (dkfz) and the department Bioinformatics and Functional Genomics at the Institute of Pharmacy and Molecular Biotechnology (IPMB) at Heidelberg University. The group is headed by Prof. Roland Eils.

 


Kallenberger 2014

Our new publication on regulation of CD95-induced apoptosis via  caspase-8 self-cleavage was highlighted in the current Science issue by senior editor L. Bryan Ray. The article by Stefan Kallenberger et al. introduces a new modeling approach of simultaneously describing single cell and population data in a cell ensemble model. Using this approach, it was unravelled how the mechanisms of caspase-8 auto-cleavage, after activation of CD95 death receptors, ensures a precise control of apoptosis at various ligand concentrations.

Further Reading:

  • Full article: Kallenberger, S.M., Beaudouin, J., Claus, J., Fischer, C., Sorger, P.K., Legewie, S., and Eils, R. (2014). Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis. Sci Signal 7, ra23-. doi: 10.1126/scisignal.2004738
  • Science Editor's Choice: Ray, L.B. (2014). A Complicated Death. Science 343, 1178-c-1179. doi: 10.1126/science.343.6176.1178-c