Welcome to the eilslabs

The eilslabs form a joint research group between the division "Theoretical Bioinformatics" at the German Cancer Research Center (dkfz) and the department Bioinformatics and Functional Genomics at the Institute of Pharmacy and Molecular Biotechnology (IPMB) at Heidelberg University. The group is headed by Prof. Roland Eils.



Stefan Kallenberger, Postdoc in the Theoretical Systems Biology group of the eilslabs, hasrecently received the second price at the Roche Oncology Award for his work on dose-dependent induction of apoptosis. The figure below gives a brief insight into his work. The prize was handed over by Klaus Bosslet, Roche’s head of Discovery Oncology in Penzberg on November 19.

Congratulations to Stefan!

cell ensemble modell Kallenberger 500px A cell ensemble model can be used to predict dose adapted optimal injection rates for a death receptor agent. After having calibrated a biochemical signal transduction model with experimental data, and having estimated parameters of the multivariate distribution of initial signaling species concentrations and tBID thresholds, surviving fractions of cells can be predicted that result from death receptor agent trajectories. It can be demonstrated, that based on a signal transduction model, dependent on pharmacodynamic parameters, optimal injection rates for a given dose of death receptor agent can be predicted. With increasing dose (D) of a death receptor agent, the optimal injection rate (arrows) increases. Source: Stefan Kallenberger