Welcome to the eilslabs

The eilslabs form a joint research group between the division "Theoretical Bioinformatics" at the German Cancer Research Center (dkfz) and the department Bioinformatics and Functional Genomics at the Institute of Pharmacy and Molecular Biotechnology (IPMB) at Heidelberg University. The group is headed by Prof. Roland Eils.

 


A recent publication by eilslabs postdoc Tobias Ahsendorf (1) is the subject of a commentary in BMC Biology by David Pincus (Whitehead Institute, 2). The comment highlights the fact that although life is an excursion away from equilibrium, common models of gene regulation are based on the assumption that it is an equilibrium process. In our paper, which was developed in collaboration between the eilslabs and Jeremy Gunawardena’s lab from Harvard Medical School, we propose a graph-based framework for modeling gene regulation that can accommodate non-equilibrium mechanisms.

Figure 3 Ahsendorf et al

From: Ahsendorf et al.BMC Biology 2014 12:102   doi:10.1186/s12915-014-0102-4

  1. Ahsendorf, T., Wong, F., Eils, R., & Gunawardena, J. (2014). A framework for modelling gene regulation which accommodates non-equilibrium mechanisms. BMC Biology, 12. doi: 10.1186/s12915-014-0102-4
  2. Pincus, D. (2015). Keeping up with the 'omics: non-equilibrium models of gene regulation. BMC Biology, 13(9). doi: 10.1186/s12915-015-0117-5