Malte Wachsmuth (EMBL) and Christian Conrad (eilslabs) recently described in Nature Biotechnology an automated systematic approach to measure fluorescence correlation spectroscopy (FCS) in living cells. They unattendly acquired more than 60,000 FCS measurements in more than 10,000 cells, which then were analyzed automatically using specialized software tools developed at DKFZ by Christian Conrad. Systems biology applications of this work are e.g. live cell proteomics and the mapping of protein behavior within cells. Further Information:
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Automatic high-throughput FCS enables systematic approches to model protein complexes using kinetic parameters in vivo. |
Measuring protein dynamics in living cells – New Publication in Nature Biotechnology
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