Welcome to the eilslabs

The eilslabs form a joint research group between the division "Theoretical Bioinformatics" at the German Cancer Research Center (dkfz) and the department Bioinformatics and Functional Genomics at the Institute of Pharmacy and Molecular Biotechnology (IPMB) at Heidelberg University. The group is headed by Prof. Roland Eils.

 


Measuring protein dynamics in living cells – New Publication in Nature Biotechnology

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Malte Wachsmuth (EMBL) and Christian Conrad (eilslabs) recently described in Nature Biotechnology an automated systematic approach to measure fluorescence correlation spectroscopy (FCS) in living cells. They unattendly acquired more than 60,000 FCS measurements in more than 10,000 cells, which then were analyzed automatically using specialized software tools developed at DKFZ by Christian Conrad. Systems biology applications of this work  are e.g. live cell proteomics and the mapping of protein behavior within cells.

Further Information:

  • Wachsmuth, M., Conrad, C., Bulkescher, J., Koch, B., Mahen, R., Isokane, M., Pepperkok, R., & Ellenberg, J. (2015). High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells. Nat Biotechnol. doi: 10.1038/nbt.3146
  • EMBL Press Release

Conrad FCS 2015 450px

Automatic high-throughput FCS enables systematic approches to model protein complexes using kinetic parameters in vivo.