Welcome to the eilslabs

The eilslabs form a joint research group between the division "Theoretical Bioinformatics" at the German Cancer Research Center (dkfz) and the department Bioinformatics and Functional Genomics at the Institute of Pharmacy and Molecular Biotechnology (IPMB) at Heidelberg University. The group is headed by Prof. Roland Eils.

 


 

"How do ovarian cancer patient cells grow in 3D culture? Can we use them in personalized drug screens?" With these questions, a collaboration between the eilslabs and Martin Sprick's and Andreas Trumpp's group at HI-STEM and DKFZ started. A newly image-based assay drug was developed and used to systematically compare drug responses between 2D and 3D. In addition in collaboration with CO group, novel links between patient drug responses and genomic aberrations were discovered, altogether laying a foundation for advanced drug screening in personalized oncology and pharmacogenomics.

Thanks to our collaboration partners and all people involved in the eilslabs!

MSB-17-7697RR_synopsis_large.jpg

Citation:

Jabs J, Zickgraf FM, Park J, Wagner S, Jiang X, Jechow K, Kleinheinz K, Toprak UH, Schneider MA, Meister M, Spaich S, Sütterlin M, Schlesner M, Trumpp A, Sprick M, Eils R, Conrad C.: Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations. Molecular Systems Biology 2017 Nov 27;13(11):955. doi: 10.15252/msb.20177697.