Welcome to the eilslabs

The eilslabs form a joint research group between the division "Theoretical Bioinformatics" at the German Cancer Research Center (dkfz) and the department Bioinformatics and Functional Genomics at the Institute of Pharmacy and Molecular Biotechnology (IPMB) at Heidelberg University. The group is headed by Prof. Roland Eils.

 


 

The iGEM Team Heidelberg 2014, supervised by Roland Eils and Barbara Di Ventura from the eilslabs, has won the Grand Prize of the iGEM competition (October 30 – November 3, 2014) in the undergraduate category. The team successfully defended their last year’s title against 245 teams from 32 countries all over the world. In addition, the team won three special prices - “Best Foundational Advance”, “Best Supporting Software” and the “iGEMer’s Price” elected by the 2.500 participants at the competition.

In their project “Ring of Fire”, the team developed a toolbox for the circularization of proteins using inteins to increase their thermostability and resistance against proteases. A circularized version of the methyltransferase DNMT1 could be used in a new PCR approach termed PCR 2.0 to transmit epigenetic marks during DNA amplification. In addition to the wet-lab work, the students developed two softwares to predict linker length and model the circularization process. Using a BOINC client, the team established the platform “iGEM@home” to use computing power from idle computers all over the world.

After the success of the iGEM Team Heidelberg 2013 with their project “Philosopher’s Stone”, which was the first German team to win the iGEM competition and this year’s success, Heidelberg is the first team ever to have successfully defended the iGEM Grand Prize in its 10-year history.

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      The iGEM Team Heidelberg 2014 and their supervisors with the BioBrick trophy.