GROUP: Theoretical Systems Biology

We are interested in cellular decision making by signal transduction networks and at the level of gene expression. We apply different theoretical methods ranging from ODE-based mechanistic modeling, over reverse engineering algorithms to agent-based modeling of cell population behaviour.


Recent Publications in the Theoretical Systems Biology Group:

  • Schmidt-Glenewinkel H, Reinz E, Eils R, Brady NR. Systems biological analysis of epidermal growth factor receptor internalization dynamics for altered receptor levels. J Biol Chem. 2009 Jun 19;284(25):17243-52 [Link]
  • Bentele M, Lavrik I, Ulrich M, Stösser S, Heermann DW, Kalthoff H, Krammer PH, Eils R. Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis. J Cell Biol. 2004 Sep 13;166(6):839-51. [Link]